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This research received funding from the Changzhou Sci-Tech Program Applied Basic Research General Project (CJ20245013, Tongbin Chen), Changzhou Medical Center of Nanjing Medical University Basic Research Program (CMCB202417, Xi Chen) and Top Talent of Changzhou The 14th Five-Year Plan High-Level Health Talents Training Project (2024CZBJ011, Xi Chen) and 2022 Annual Youth Talent Science Project of the Health Commission of Changzhou City (QN202217, Wenyue Da)

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High energy-demanding cells, such as tubular epithelial cells, colonocytes, and myocytes, often use this energy pathway as their main metabolic pathway

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Given the central role of citrate in the tricarboxylic acid cycle, its depletion may signal compromised aerobic respiration, possibly driven by heightened oxidative stress or inflammation, two processes well documented in epileptogenesis 7,12,13,14,15

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