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In a chronic model, mice were treated with Icariin 25 mg per kg administered intraperitoneally to 10 days before the initial dose of CYP that is 75 mg per kg given through an intraperitoneal route every 3 days for about 10 days to decrease the edema and hemorrhage of bladder, vascular permeability, and mast cells infiltration as well as fibrosis of the lesion tissue

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Year 2014 Mechanisms underlying the antihypertensive effects of garlic bioactives Garlic and Oxidative stress Oxidative stress is one of multiple molecular mechanisms involved in the etiology of hypertension

A mast cell is a type of specialized white blood cell that serves as the alarm system for the immune system

Pharmacological therapies targeting GPX4 are a promising strategy for inducing ferroptosis in cancer cells, including clear-cell carcinomas that resistant to conventional treatments [49]