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Survival analysis was done with the Kaplan-Meier survival curve

These findings indicate a potential new approach for the treatment of HCC recurrence and metastasis [102]

Additionally, while ceramides promote apoptosis by BAX dependent mechanisms, sphingolipid metabolism co-operates with BAK/BAX dependent mechanisms to promote permeabilization of the mitochondrial outer membrane (MOMP) (135, 136)

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It is evident that different in vivo models develop a broad spectrum of symptoms and severity according to the species, but also to the technique adopted for their generation