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Drug Interactions: Use with Xanthine Oxidase (XO) Inhibitors: One of the pathways for inactivation of azathioprine is inhibited by XO inhibitors (allopurinol or febuxostat)

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funding acquisition: DR and TR All authors have read and agreed to the published version of the manuscript

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During degeneration, there is a reduction in the number of nucleus pulposus cells (NPCs), resulting in an imbalance between the synthesis and degradation of the ECM, leading to changes in the discs morphology and biomechanical function, ultimately causing pain and mobility issues