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S4E, F, depletion of GGCT in HCC and PCa cells led to G 2 /M phase arrest and decreased CCNB1 and CDK1 and p-CDK1 protein levels

1 are reversible, class I glutaredoxins can also catalyze the GSSR- or GSSG-dependent glutathionylation of thiols or the formation of (protein) disulfides 3,5,35,61

In some cases, vacuolar peptidases may cleave the glutamate and glycine of the original glutathione molecule, leaving the cysteinyl conjugate (cysteine-X) which may need further processing in Phase III reactions, such as incorporation into cell wall material