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A population-based study in 3,884 elderly men and women with depressive disorders found that those with vitamin B 12 deficiency were almost 70% more likely to experience depression than those with normal vitamin B 12 status (98)

doi: 10.1056/NEJMoa1505489

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The fact is that when tablets were introduced as therapy in other countries there simply wasnt any credible patient support group to put forward the views of the patients

In some studies, in which treatment discontinuation resulted in missing data, post-discontinuation assessments were imputed using the LOCF approach [26, 27, 30,31,32]