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( C ) After an 8-hour exposure to the conditions described at left, TUNEL labeling (red, with DAPI counterstain in blue) was performed in 5 independent replicate experiments, with 5 independent fields examined for each condition in each experiment

Furthermore, confounding risk factors which influence cardiovascular health (e.g., smoking and hypercholesterolaemia) are absent in murine models and as such their hearts reflect intrinsic cardiac aging ( Despite differences with regards to heart rate, heart size, as well as calcium- and potassium-mediated repolarization currents, which limits their ability to model conditions such as LQT1 and LQT2, murine and human hearts show significant structural and physiological resemblances (65)

10.1073/pnas.1807305115 Proc

Based on the age of onset, AD is classified into early-onset AD (EOAD, 80%), serves as a preferred target for peroxidation during ferroptosis (94)

doi: 10.1016/j.biopha.2024.117510 148 ChenMZhangRChenYChenXLiYShenJet al