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Anticancer Drug Encapsulation Use Case: Chemotherapeutic delivery with reduced toxicity Challenge: Many anticancer agents (e.g., doxorubicin, paclitaxel) are highly potent but poorly soluble and systemically toxic

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Therefore, in the IPPS final rules spanning the period from FY 2005 through FY 2016, we adjusted the national inpatient PPS rates by an amount sufficient to account for the added costs of this demonstration program, thus applying budget neutrality across the payment system as a whole rather than merely across the participants in the demonstration program

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J Physiol 558(Pt 1):225237 Fukushima A, Milner K, Gupta A, Lopaschuk GD (2015) Myocardial energy substrate metabolism in heart failure: from pathways to therapeutic targets