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Differentiating between gout and asymptomatic hyperuricemia can be challenging, as gouty nephropathy may occur even in the absence of clinically apparent gout or with serum uric acid levels below the solubility threshold

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J Neurochem 82:458467 Huang CS, Chang LS, Anderson ME, Meister A (1993) Catalytic and regulatory properties of the heavy subunit of rat kidney -glutamylcysteine synthetase

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The main enzymatic antioxidants are catalase, GPx and SOD while reduced glutathione, vitamin C, vitamin E, carotene, ceruloplasmin and bilirubin are non-enzymatic factors [21]