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Biochemistry 55, 53075315

StatPearls [Internet]

This configuration supports receptor-level interaction within adipocytes while minimizing affinity for the growth hormone receptor, distinguishing it from full-length GH and preventing downstream IGF-1 pathway activation

[DOI] [PubMed] [Google Scholar] 6.Jensen MD, Ryan DH, Apovian CM, Ard JD, Comuzzie AG, Donato KA, Hu FB, Hubbard VS, Jakicic JM, Kushner RF, Loria CM, Millen BE, Nonas CA, Pi-Sunyer FX, Stevens J, Stevens VJ, Wadden TA, Wolfe BM, Yanovski SZ G

This means that unexplained, persistent high B12, especially when it is not caused by supplements, should not be ignored

But it supports energy and metabolism, which makes the weight-loss work easier especially alongside GLP-1 treatment