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For instance, synthetic active ingredients from natural extracts could not exert the antioxidant effects of natural extracts in several clinical intervention trials (Salvayre et al., 2016)

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Upregulation of NCOA4 promotes lysosomal degradation of ferritin, leading to a sharp expansion of the intracellular labile iron pool, which provides the essential iron substrate for ferroptosis and directly lowers the threshold for ferroptosis initiation (83)

It has been found that long-term exposure to monthly fipronil treatments has selected for resistant flea strains (22), and resistant Dirofilaria immitis strains that cause heartworm disease have emerged (23)

[] Nevertheless, the nonselective clearance of uremic toxins can positively impact sepsis