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Published data suggests up to 2.6% incidence of B12 deficiency within a year of treatment, and this figure climbs in patients who have used these medications long term or combined them with very low calorie diets (3)

This approach would allow for precise regulation of HO-1, inhibiting its harmful effects while preserving its antioxidative function

Ethics declarations Competing interests The authors declare no conflict of interest

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Therefore, varying drugs, including antidiabetics, antioxidants, lipid-lowering drugs, probiotics, and anti-platelets, which might have potential beneficial effects, have been continuously investigated in patients with CLD [8-15]

Savvides P, Nagaiah G, Lavertu P, Fu P, Wright JJ, Chapman R, et al