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This observation motivates a second paper by Maestas and Sherry, Opioid Treatment for Pain and Work and Disability Outcomes: Evidence from Health Care Providers Prescribing Patterns (NBER RDRC Working Paper 19-28-2)

DISCUSSION Porphyrias comprise a group of clinically heterogeneous metabolic disorders, mostly caused by inherited defects in enzymes involved in heme biosynthesis (14) and subsequent accumulation of biosynthetic intermediates, predominantly in the liver (hepatic porphyrias) or erythrocytes (erythropoietic porphyrias) (1, 4)

Gvercin, S., Erat, M., & akirolu, H

Duan, X., Krishnaswamy, A., De la Huerta, I

Machine learning models using these data sets show promise but still require validation in diverse cohorts