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2 PMC NAD+ Metabolism ReviewComprehensive review of NAD+ metabolism, mitochondrial function and aging

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Fully pluripotent stem cells like embryonic stem cells (ESCs) are theoretically the ideal cell type in terms of regenerative potential, but ethical concerns, limited cell numbers and sources for harvest, and immunologic reactions after implantation hinder application of these cells

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finally, by eliminating the target protein, PROTACs can abolish all of its functions and potentially overcome acquired resistance due to binding site mutations [309, 311]

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