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Decreased stomach acid production also provides an environment conducive to the overgrowth of anaerobic bacteria in the stomach, which further interferes with vitamin B 12 absorption (3)

At a dose equivalent to human exposure at the 5 mg intravenous dose, the effect persisted for 8 months, which corresponds to approximately 8 remodeling cycles or 3 years in humans

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Toxics 11 , 40 (2022)

Many people, especially those with certain dietary restrictions, may not get enough B12 from their diet