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Li Y, Hecht SS (2022a) Metabolic activation and DNA interactions of carcinogenic N-Nitrosamines to which humans are commonly exposed

This mechanism may reduce the capacity of cells to repair DNA damage, increasing genomic instability and promoting apoptosis

Four solutions were prepared: 100 % methanol, methanol/water (50:50) (v/v), methanol + 0.01 % acetic acid, and ammonium buffer pH 3.5 [H 2 O/ACN (90:10) (v/v) + 1 mM NH 4 (CH 3 COO)]