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doi: 10.1111/j.1365-2982.2009.01302.x 31 GulbransenBDBashashatiMHirotaSAGuiXRobertsJAMacDonaldJAet al

interim monitoring of creatinine clearance should be performed in at-risk patients

(2018) 42:e12579

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We determined enzymatic production is primarily driven by CGL and predominates in the liver and kidney, whereas non-enzymatic production prevails in the majority of other tissues