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They can down-regulate gene expression by binding to their target mRNA and inhibiting its translation through the creation of a steric block to ribosome binding and/or by facilitating RNase H recruitment and RNA cleavage

The forkhead box O (FOXO) family of transcription factors (especially FOXO3), which serve as crucial regulators of ROS levels in cellular antioxidative defense systems, is essential for maintaining the HSC pool [115,116,117]

This was followed by the quick addition of 1.250 mL of d-PLL (200 mM) as a coating ligand and 0.39 mL of ascorbic acid (0.1 M) as a reducing agent

doi: 10.3389/fnut.2023.1120293 64 StreetMEAngeliniSBernasconiSBurgioECassioACatellaniCet al

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-Synuclein Alters Toll-Like Receptor Expression