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Zhou JF, Wang XY, Shangguan XJ, Gao ZM, Zhang SM, Xiao WQ, Chen CG: Increase oxidative stress in women with pregnancy-induced hypertension

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Aspirin Acetylates TrxR1 and Provides Robust Resistance to Oxidative Damage Protein acetylation can occur specifically in cells resulting from the activity of acetyltransferases, but also non-specifically through interactions with acetyl donors including acetyl-CoA or certain drugs, such as aspirin ( A previous report used incubated HeLa cells with a range of aspirin concentrations from 0.5 to 20 mM to generate aspirin-mediated and non-specific acetylation of many cellular proteins, including TrxR1 (Figure 5)

doi: 10.1038/d41586-020-00296-x