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Oligodendrocytes are particularly vulnerable to cuprizone-induced mitochondrial dysfunction 7 , resulting in apoptosis 1 and subsequent loss of myelin 4

3.2.3 FUNDC1 mediated mitophagy The FUN14 domain-containing protein 1 (FUNDC1) is widely present on the mitochondrial outer membrane and acts as a regulator of mitochondrial autophagy in response to hypoxia, inducing Parkin-independent mitophagy (Zhang W