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Immune checkpoint inhibitors and ferroptosis inducers have been shown to work in concert in preclinical models to enhance anti-tumor immunity and cancer cell death (Cai et al

In reproductive medicine, for instance, multiple studies have shown that Endo/Whole-UdECM hydrogel derived from pig uterus can significantly promote the regeneration of thin endometrium, restore embryo implantation capacity, and improve fertility rates by modulating the IGF1/IGFBP3 signaling axis and reshaping uterine NK cell subsets 175

Mei J, Xu D, Wang L, Kong L, Liu Q, Li Q, et al

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Similarly, MRTX849 treatment decreased intratumoural immunosuppressive myeloid-derived suppressor cells and M2-polarised macrophages and increased immune-promoting M1-polarised macrophages, dendritic cells, and CD4 + and NKT cells in KRAS (G12C) tumours by altering the expression of tumour RNA and protein implicated in the presentation of tumour antigens or mediating an immunosuppressive TME 204