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Am J Physiol Endocrinol Metab 308(2):E97-e110

8, 15, 16 Activation of the glial cells may also have noxious consequences on neurons, as they may cause mechanical damages and alterations of the microenviroment

The IGF-1 (Insulin-like Growth Factor 1) pathway is a signaling cascade including the IGF-1R receptor, PI3K kinase, Akt kinase and downstream effectors