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Intravenous ketamine may be effective in treating major depression [160], and this NMDA receptor antagonist is under investigation in two phase 2 trials in participants with PD and depression (NCT04944017, NCT06231563), but results are not yet available

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Common sense would suggest halving the daily dose to achieve a target concentration of 1 ng/mL

We next examined immunovascular interactions in PBMCs isolated from patients with COVID-19 and found increased adhesion of PBMCs to human brain endothelial cells in the cohort with long COVID compared to unaffected individuals, which was heightened in the presence of TNF and only modestly affected by blocking antibodies against ICAM-1 and VCAM-1 (Extended Data Fig

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