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falciparum 3D7A was cultured in human O+ erythrocytes in complete RPMI 1640 (Sigma Aldrich) medium supplemented with 0.5% (w/v) Albumax II (Invitrogen), 0.2% (w/v) NaHCO3, 0.2% (w/v) Glucose, 200 M Hypoxanthine and 5 g/L Gentamycin

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10.1186/1471-2202-7-24 BMC Neurosci

To date, it has been observed that the treatment with this kind of antitumor agents causes ROS generation, mitochondrial dysfunction (including frataxin deficiency, mitochondrial DNA damage and defective components of ETC), loss in antioxidant enzymes, ion channels disturbances and nerve tissue damage (protein carbonylation and lipid peroxidation) (Areti et al., 2014