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Success will require sustained investment in basic research to understand fundamental mechanisms, clinical research to test therapeutic hypotheses, and technological development to enable precision metabolic medicine

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IGF-1 Side Effects: It should be noted that high doses of IGF-1 have been known to cause hypoglycemia, but nowhere near the level of insulin

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We approached this by identifying omics- features (i.e., expression, mutation, copy number, pathways, metabolites, etc.) that are predictive of NRF2 CRISPR knockout scores from the DepMap