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Modulating the viscosity of GRg3@RHT NS could improve naso-brain transport efficiency by bypassing the BBB, facilitating effective treatment of AD by multi-targeted therapy

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After scratching the cells to make a wound, 3 10 9 particles of fluorescently labeled l-EVs were added to the 4 10 6 cells in 200 l of phenol red-free DMEM medium (Gibco, #21063029) containing 10% EV-depleted FBS, and the cells were incubated for 1 h before the observation

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The metabolism of these compounds by GT positive tumor cells should produce high local concentrations of bioactive and membrane permeable metabolites that would then block tumor cell proliferation and eventually tumor growth

Examples include CD95 (Fas) and TNF-related apoptosis-inducing ligand (TRAIL)-receptor (TRAIL-R) that are activated by their ligands, Fas ligand (FasL) and TRAIL, present on NK cell membranes or secreted by NK-derived exosomes