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Excessive autophagy might lead to cell death, which is a new way of cell death in addition to apoptosis and necrosis [128]

Methods: Using human cholangiocyte cell lines, we investigated the colocalization of DNA repair proteins at the cilia base and examined how experimental deciliation affects DNA repair pathways, leveraging RNA sequencing data for comprehensive insight

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Nature (2014) 509:4926

Similar content being viewed by others Introduction Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease of largely unknown etiology leading to death within 34 years after diagnosis 1