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Two community-derived dosing models dominate

The Cardiac Arrhythmia Suppression Trials (CAST I and II) showed that patients with a history of myocardial infarction, treated with class IC agents (flecainide, encainide, moricizine) to reduce premature ventricular contractions (PVCs), faced a higher mortality risk compared to those receiving a placebo (72)

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This range approaches the levels of surgical anesthesia and can suppress vital life-supporting reflexes, leading to a loss of consciousness and, without immediate medical intervention, a severe risk of coma or death