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By incorporating peptide sequences into the linker, cleavage occurs only in tumor cells or endosomal/lysosomal compartments with specific enzyme activity, enabling selective payload release, improving drug targeting, and reducing toxicity to healthy tissues

This synergy may happen by CCK activating brainstem neurons which project to the hypothalamus combined with the direct hypothalamic actions of leptin

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Here, we highlight the differences in arginase compartmentalization and storage between humans and rodents that should be taken into consideration when assessing the effects of arginase activity