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Toxicol Appl Pharmacol 18(3):562572 Gaetke LM, Chow CK (2003) Copper toxicity, oxidative stress, and antioxidant nutrients

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Meanwhile, a glucose-lowering formulation containing hawthorn polyphenols, D-chiro-inositol, and epigallocatechin gallate exhibited synergistic hypoglycemic activity, markedly improving insulin resistance in mice, decreasing fasting blood glucose and hepatic gluconeogenesis, and enhancing hepatic glycogen synthesis and storage (Peter et al., 2012)

1 Introduction Graves disease (GD), an autoimmune thyroid disease (AITD), is the most prevalent cause of hyperthyroidism, potentially resulting in goiter, protruding eyeballs, pretibial mucous edema, and an elevated metabolic state, all of which pose significant health risks ( Research has revealed the importance of critical metals for several typical physiological processes and activities, including copper (Cu), iron (Ir), zinc (Zn), and calcium (Ca)