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For patients with more severe RLS or who do not respond adequately to first-line therapy, combination therapy and the use of opioids should be strongly considered

KG-mediated carnitine synthesis promotes homologous recombination via histone acetylation

References Eldisouky AA, Hegazy SK, Abd Elghany SE

Fatigue was quantified with the PROMIS v1.0 Fatigue (PROMIS-Fatigue) Short Form 7a, which measures the impact in the last 7 days that fatigue has on daily life (Ameringer et al., 2016)