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Key milestones include: Growth hormone deficiency : Multiple Phase 3 RCTs demonstrating efficacy for linear growth in GH-deficient children, with catch-up growth velocities of 10-12 cm/year in the first treatment year Adult GH deficiency : Controlled trials showing improved body composition (reduced visceral fat, increased lean mass), bone mineral density, and quality of life Turner syndrome : FDA-approved indication with documented growth velocity improvement AIDS wasting : Approved for HIV-associated wasting syndrome, demonstrating lean mass preservation Chronic renal insufficiency : Approved for growth failure in pediatric CKD patients The safety database spans decades of post-marketing surveillance across millions of patient-years, providing detailed understanding of both short-term and long-term risks

More practical doses for general supplementation have not been established

Dilip Mehta, Anslem Desouza To view or add a comment, sign in Diabetic Ketoacidosis (DKA) A

TCC-treated wounds also had significantly lower concentrations of TNF-alpha and MMP-2 and MMP-9, indicating reduced inflammation and enhanced healing

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The RDA for vitamin B12 is 2.4 mcg per day