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Excess ROS can damage all major cellular constituents (DNA, proteins, and lipids) and even lead to cell death, apoptosis, hypertrophy, fibrosis, and contractile dysfunction in the myocardium [8, 11]

On the other side, other terpenoids such as carotenoids, retinoids, and tocopherols exhibit a high degree of hydrophobicity that may be attributed to its interaction with the highly hydrophobic N-terminal acetylation domain of -Syn (Oliveri 2019)