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The first pathway involves the enzymes indoleamine 2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO), which break down Trp through the kynurenine (Kyn) pathway

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Furthermore, activated IKK mediates the Ser536 phosphorylation of NF-B p65 to initiate reverse transcription, resulting in increased transcriptional activation [35, 36]

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Research suggests curcumin reduces oxidative stress in psoriatic lesions and inhibits elevated phosphorylase kinases, a key factor in psoriasis pathology (553)