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Excess iron can damage the liver, heart and pancreas in these conditions [31] [35]

In contrast, the ATRA + ATO and ATRA-ATO-NPs showed significant inhibition on the viability of HuH7 and Hepa1-6 cells, indicating that the combination of ATRA and ATO had a synergistic effect on inhibiting cell growth

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Conclusions Our study reveals SLC25A39 as a critical regulator of HCC progression via the mitochondrial ROS-cytochrome c -caspase signaling axis, highlighting its potential as a diagnostic biomarker and therapeutic target in HCC