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Although some patients develop a mild rash to allopurinol that remains mild over time, or respond to antihistamines, continuing the allopurinol despite a rash is not advised, since the rash can worsen unpredictably

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10.1016/j.schres.2010.07.020 290

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Migliorini F, Pilone M, Simeone F, Jeyaraman M, Bell A, Maffulli N