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The tumor microenvironment, characterized by hypoxia, inflammation, and high metabolic activity, is another critical aspect of cancer influenced by oxidative stress [107]

Santos VBd, Guerreiro TB, Suarez WT, Faria RC, Fatibello-Filho O

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Biochem J 370:771784 Peterse EFP, Niessen B, Addie RD et al (2018) Targeting glutaminolysis in chondrosarcoma in context of the IDH1/2 mutation

In one study on a TNBC model, a tumor acidity-responsive nanoparticle released chemokine C-C motif ligand 25 (CCL25) protein and cluster of differentiation 47 (CD47) siRNA sequentially after intra-tumoral administration, and therefore enhanced immunotherapy against the cancer cells by promoting CCR9+ CD8 + T cell tumor infiltration (Chen et al., 2020)