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The maximum reported dosage for general health is 6080 drops (3040 mg/day), aligning with the lower end of 0.5 mg/kg for the average person Methylene blue drops are often sold as a 1% solution (10 mg/mL), where 1 drop contains 0.5 mg

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Metab Brain Dis 39:16131636 Mc Hugh R, McBride O (2020) Self-medicating low mood with alcohol use: examining the role of frequency of alcohol use, quantity consumed and context of drinking

This deletion abolishes IGFBP binding while preserving IGF-1R affinity, making DES locally hyperactive but highly labile (half-life of a few minutes)

doi: 10.1080/87559129.2023.2230268 282 CuiSGuJLiuXLiDMaoBZhangHet al

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