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Similar content being viewed by others Introduction Myalgic encephalomyelitis/chronic fatigue syndroome (ME/CFS) is a chronic disease with disability, fatigue, post-exertional malaise (PEM), cognitive lapses, nonrefreshing sleep, interoceptive distress, pain and orthostatic complaints 1,2,3,4

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These effects occur in a minority of users and rarely require discontinuation

Introduction Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) or Systemic Exertion Intolerance Disease (SEID) ( ME/CFS impacts all ages, races, and socioeconomic groups ( Due to the disabling symptoms which include cognitive and physical impairment worsened by exertion ( In this review paper, we will focus on describing ME/CFS in terms of symptoms, severity and burden, diagnostic criteria, causes and triggers