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Serna Salas 1 , Magnolia Martnez 2 , Aniek Vlasma 3 , Manon Buist-Homan 2 and Han Moshage 1 , (1)University Medical Center Groningen, (2)University Medical Center of Groningen, (3)Umcg Background: Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD) is the most common liver disorder worldwide

Cancer treatment including chemotherapy, radiation, immunotherapy, endocrine therapy, and cold capping can adversely affect the constitution of patients

Its highest concentrations are found in the liver, the bodys central organ for detoxification, where it plays a vital part in neutralizing harmful free radicals, supporting phase I and phase II liver detoxification pathways, and helping to eliminate heavy metals and environmental toxins

Poor Diet : Deficiencies in essential nutrients can impair synthesis

Conclusion Hyaluronic acid can cause bloating due to its water-binding properties and effects on digestive function

In plasma, it is released through enzymatic degradation of larger proteins, particularly SPARC (secreted protein acidic and rich in cysteine, also called osteonectin) and collagen