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Studying mitophagy has been challenging in -cells, and its relevance was brought into question when loss of function studies on Parkin, a key regulator of mitophagy through ubiquitin-dependent autophagosome degradation, in -cells revealed no overt phenotype (Corsa et al., 2019)

JCI Insight 2 (7), e90777

235 H 2 O 2 also increases threonine phosphorylation in Caco-2 cells by downregulating PP2A via oxidation of its redox-sensitive Cys266 and Cys269, forming inhibitory disulfide bonds, 236 particularly through oxidation of the B55 isoform

With the widespread use of antifungal agents, resistance among Candida species has become increasingly concerning, especially with the emergence of multidrug-resistant strains such as Candida auris , now recognized as a global health threat (Clancy and Nguyen, 2016

J Chengde Med Coll

88 Nevertheless, RAG-independent activation of mTORC1 by amino acids has been described in both yeast and human cells