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Side effects are generally mild (injection site reactions, transient fatigue) and dosage-dependent

In some studies, the 5-lipoxygenase inhibitor zileuton, when co-administered with PGE2, reduced pulmonary bacterial burden and pathology and prevented acute death in M.tb -infected mice deficient in both IL1R1 and IFNAR1 [129]

doi: 10.1128/AEM.02553-12 172 MironJBen-GhedaliaDMorrisonM

however, because of its limited sensitivity, a trial of antibiotics may be warranted based on clinical suspicion [106]

Environmental factors such as chronic air pollution, smoking, and hypoxic conditions also modulate hemoglobin levels and oxidative stress, influencing systemic aging pathways [47,48]

Therapeutic efficacy of aortic administration of N-acetylcysteine as a chemoprotectant against bone marrow toxicity after intracarotid administration of alkylators, with or without glutathione depletion in a rat model