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Tumor microenvironment metabolism: a new checkpoint for anti-tumor immunity

In SH-SY5Y cells treated with BSA-PC, phosphorylation of the mitochondrial fission marker dynamin-related protein 1 (DRP1) and mitochondrial fission factor (MFF) fragments increased compared to cells treated with BSA alone (Fig 3A and 3B)

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doi: 10.1016/j.jaut.2022.102890 5 DixonSJOlzmannJA

In particular, experimental studies indicate that elevated oxidative stress can be found in PLTs when incubated with thalassemic RBCs compared with normal RBCs, leading to increased PLT activation (5)