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In addition, -syn aggregation and related factors disrupt MAMs, perturbing Ca 2+ uptake and release during cytosolic transients and resulting in Ca 2+ overload in both the cytosol and mitochondria (Paillusson et al., 2017)

doi: 10.1016/j.cell.2022.12.032, 7

In this study, exposure to 500 M SM resulted in increased activation of the nuclear transcription factor (NF kB ) binding to its consensus sequence 5 h after exposure

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One of the most intriguing observations in this context was the desensitization of cells pretreated with NFT for glutathione induction in response to secondary stressors

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