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Cancer cells face a range of intrinsic and extrinsic adverse/stressful conditions, such as nutrient and oxygen deficiency, and have consequently developed means to adapt their metabolism in order to survive

10.1161/CIRCRESAHA.107.152942 Circ Res

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Chem Biol Interact 192(12):101106 Dinkova-Kostova AT, Holtzclaw WD, Cole RN, Itoh K, Wakabayashi N, Katoh Y et al (2002) Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

R.et al (2020)

169 The current view is that c-Kit may play a double-edged role in the liver: on the one hand, c-Kit-positive cells participate in tissue repair by promoting target cell regeneration in the event of liver injury, but on the other hand, the overexpression or mutation of c-Kit as a proto-oncogene contributes to the development of HCC