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In the transsulfuration pathway, homocysteine is converted to cysteine through a series of enzymatic reactions catalyzed by cystathionine -synthase (CBS) and cystathionine -lyase (CGL)

The human glutathione S-transferase, possess both enzymatic and non-enzymatic functions and are involved in many important cellular processes, such as, phase II metabolism, stress response, cell proliferation, apoptosis, oncogenesis, tumor progression and drug resistance

However, the NF-B signaling is uncontrolled when the R702W gene is mutated, protecting the organism against the harm caused by oxidative stress induced by H

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Two synergistic models are envisioned: a sequential approach, where CAR-Ms first precondition the microenvironment by clearing antigenic debris and immune complexes to enable safer, more effective CAR-T deployment against pathogenic lymphocytes

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