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Oncolytics 20 , 228239 (2021)

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In this context, a study conducted on rats fed a high-fat diet found that Spirulina supplementation was administered

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To evaluate the ER stress activity, we performed p-IRE1- immunolabeling and western blotting on 12Z cells

Abbreviations 8-oxodG: 8-oxo-7,8-dihydro-2-deoxyguanosine 8-oxoGuo: 8-oxo-7,8-dihydroguanosine ABTS: 2,2-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) ADP: Adenosine diphosphate Akt: Protein kinase B ALD: Alcoholic liver disease AMPK2: AMP-activated protein kinase 2 ARE: Antioxidant responsive element ASCVD: Atherosclerotic cardiovascular disease ASD: Autism spectrum disorder ATP: Adenosine triphosphate BAIBA: -Aminoisobutyric Acid BAX: BCL-2-associated X protein Bcl-2: B cell lymphoma-2 BDNF: Brain-derived neurotrophic factor BMI: Body mass index CAT: Catalase CCL28: C-C motif chemokine ligand 28 CD31: Platelet endothelial cell adhesion molecule 1 CHD: Coronary heart disease CHF: Chronic heart failure CL: Cardiolipin CVDs: Cardiovascular diseases CXCL4: C-X-C motif chemokine 4 DCM: Diabetic cardiomyopathy DIC: Doxorubicin-induced cardiotoxicity DMG: N, N-dimethylglycine EcSOD: Extracellular superoxide dismutase eNOS: Endothelial nitric oxide synthase ER: Endoplasmic reticulum ER: Estrogen receptor ETC: Electron transport chain FAO: Fatty acid oxidation FGFR1: Fibroblast growth factor receptor 1 FGF21: Fibroblast growth factor 21 FNDC5: Fibronectin type III domain-containing protein 5 FOXO3: Forkhead box protein O3 GCH1: Guanosine triphosphate cyclohydrolase I GLUT4: Glucose transporter type 4 GPx: Glutathione peroxidase GSH: Glutathione GSSG: Glutathione disulfide H 2 O 2 : Hydrogen peroxide HF: Heart failure Higd1a: Hypoxia-induced gene domain family member-1a HIIT: High-intensity interval training HO-1: Heme oxygenase-1 Hsp90: Heat-shock protein 90 I/R: Ischemia/reperfusion IDH2: Isocitrate dehydrogenase 2 IGF-1: Insulin-like growth factor 1 IL-6: Interleukin-6 IL-10: Interleukin-10 IL-1: Interleukin-1 InsR: Insulin receptor KLF2: Krppel-like factor 2 K V 1: Voltage-gated potassium MAPK: Mitogen-activated protein kinase MCP-1: Monocyte chemoattractant protein-1 MDA: Malondialdehyde Mecp2: Methylated CpG-binding protein 2 METTL3: N6-adenosine-methyltransferase-like 3 MG53: Mitsugumin 53 MI: Myocardial infarction MICT: Moderate-intensity continuous training MitoQ: Mitoquinone MMP2/9: Matrix metalloproteinase 2/9 MMPs: Matrix metalloproteinases MnSOD: Manganese superoxide dismutase MOTS-c: Mitochondrial open-reading-frame of the 12 S rRNA-c mPTP: Mitochondrial permeability transition pore mtROS: Mitochondrial reactive oxygen species NADPH: Nicotinamide adenine dinucleotide phosphate NAFLD: Nonalcoholic fatty liver disease NASH: Nonalcoholic steatohepatitis NFE2L2: Nuclear factor erythroid 2-related factor 2 NO: Nitric oxide Ereg: Epiregulin NOX2: NADPH oxidase 2 NOX4: NADPH oxidase 4 NQO1: NAD(P)H quinone oxidoreductase 1 Nrf2: Nuclear factor erythroid 2-related factor 2 NSE: Neuron-specific enolase PAI-1: Plasminogen activator inhibitor-1 PAR2: Protease-activated receptor 2 PGC-1: Peroxisome proliferator-activated receptor coactivator-1 PINK: PTEN-induced putative kinase 1 PI3K: Phosphoinositide 3-kinase POMC: Proopiomelanocortin PPAR: Peroxisome proliferator-activated receptor RNS: Reactive nitrogen species ROS: Reactive oxygen species SIRT1: Sirtuin 1 SIRT3: Sirtuin 3 SkQs: Cationic plastoquinone derivatives S-NO: S-nitrosylation SOD: Superoxide dismutase SR: Sarcoplasmic reticulum STAT3: Signal transducer and activator of transcription 3 T2DM: Type 2 diabetes mellitus TAC: Total antioxidant capacity TCA: Tricarboxylic acid TGF-: Transforming growth factor- TNF-: Tumour necrosis factor- UCP2: Uncoupling protein-2 UPR mt : Unfolded protein responses WAT: White adipose tissue YBX1: Y-box binding protein 1 -END: -endorphin GCLC: Catalytic subunit of gamma-glutamylcysteine ligase References Xu S, Bai P, Little PJ, Liu P