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The antioxidant substances we used also inhibit the NF-kB factor, a transcription factor for the production of pro-inflammatory and pro-fibrotic cytokines [32,33,34,35,36,37,38]

In most cases, such diagnoses can be ruled out through clinical history and physical examination.1,2,4 With only a few reports, lingual melanotic macule is considered a rare or underdiagnosed entity.1,2 In a review of the literature in 2015, Savoia et al