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262 WangY.DuanC.DuX.ZhuY.WangL.HuJ.et al

Combination approaches simultaneously address multiple bottlenecks, enabling faster overall progress through the repair cascade

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doi: 10.1016/j.jhep.2023.07.021 9

They revealed that BHD diminishes lactylation modifications, including Pan-Kla and H3K18la, by restricting lactate synthesis, which leads to the normalization of apoptotic protease activating factor-1 (Apaf-1) transcription levels and ultimately promotes cellular survival [126]