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[21] When HCPCS code 0686T was first effective, the histotripsy procedure was designated as a Category A IDE clinical study (NCT04573881)

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This conformational change further transduces through F279 6.51 and H280 6.52 to cause rearrangement of an aromatic cluster formed by residues W276 6.48 , F279 6.51 , H280 6.52 , and F312 7.42 (Fig